Anti-cancer effect of hydrogen sulfide: an example of host- bacterial mutualism in oral cancer
نویسندگان
چکیده
The incidence of oral cancer is lower than that of other common cancers. Understanding the factors that contribute to the decreased incidence of oral cancer may be useful for decreasing the incidence of cancer overall. We focused on the effects of hydrogen sulfide, which is produced by oral bacteria. We report that hydrogen sulfide induced apoptosis in gingival cancer cells that overexpressed pleckstrin homology-like domain, family A, member 1 (PHLDA1), but not in keratinocytes that were derived from healthy gingiva. The anti-cancer effect of hydrogen sulfide may indicate the existence of a host-bacterial mutualism in oral cancer. The role of PHLDA1 as an apoptosis suppressor is also discussed.
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